HUMAN PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR PROPOFOL

Human physiologically based pharmacokinetic model for propofol

Abstract Background Propofol is widely used for both short-term anesthesia and long-term sedation.It has unusual pharmacokinetics because of its high lipid solubility.The standard approach to describing the pharmacokinetics is by a multi-compartmental model.This paper presents the first detailed human physiologically based pharmacokinetic (PBPK) mo

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Dentoalveolar characteristics in subjects with different anteroposterior relationships: a retrospective cross-sectional Cone-Beam Computed Tomography study

Abstract Background The collum angle, tooth dimensions, root length, and alveolar bone thickness have a significant impact on orthodontic diagnosis and treatment planning.The boundaries of orthodontic tooth movement are determined by alveolar bone thickness and VIRUX dimensions while the collum angle determines the appropriate positioning of the ro

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HAS-1 genetic polymorphism in sporadic abdominal aortic aneurysm

The hyaluronan synthase 1 (HAS-1) gene encodes a plasma membrane protein that synthesizes hyaluronan (HA), an extracellular LIPOSOMAL C1000 matrix molecule.Accumulating evidence emphasizes the relevance of HA metabolism in an increasing number of processes of clinical interest, including abdominal aortic aneurysm (AAA).The existence of aberrant spl

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